Relations for substrate

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Entity 1	Relationship	Entity 2	Article	Frequency	Score
testosterone	employed-as	substrate	Studies on the metabolism of steroid hormones in a virilizing adrenal cortex adenoma.	16	40.7791
substrate	binds-to	enzyme	Evidence against a covalent intermediate in the adenosine triphosphate phosphoribosyltransferase reaction of histidine biosynthesis.	23	38.6336
acetate	employed-as	substrate	Carboxylic ester hydrolases in the thyroid gland of the guinea-pig. A light microscopic study.	10	34.7791
progesterone	employed-as	substrate	Biosynthetic pathways for corticoids and androgen formation in human fetal adrenal tissue in vitro.	8	32.7791
substrate	containing	propeptide	Expression and characterization of the naturally occurring mutation L394R in human gamma-glutamyl carboxylase.	3	32.4249
substrate	including	oxaloacetate	Characterisation of the two malate dehydrogenases from Phytomonas sp. Purification of the glycosomal isoenzyme.	1	32.1693
substrate	contained	phosphate	Correlated biochemical and cytochemical studies of nicotinamide adenine dinucleotide phosphatase (NADPase) activity in ameloblasts using structural analogues of NADP.	1	31.9182
aldehyde	serves-as	substrate	The nucleotide sequence of the luxE gene of Vibrio harveyi and a comparison of the amino acid sequences of the acyl-protein synthetases from V. harveyi and V. fischeri.	3	31.7679
succinate	applied-as	substrate	Functional and structural changes in isolated rabbit liver mitochondria induced by fluorodichloromethane.	23	31.6699
thiocyanate	followed	substrate	Kinetics and modeling of autotrophic thiocyanate biodegradation.	1	31.5558
ubiquitin	employed-as	substrate	Multiple ubiquitination of calmodulin results in one polyubiquitin chain linked to calmodulin.	2	31.4518
substrate	containing	amino	Heparin in calcification prevention of porcine pericardial bioprostheses.	3	31.0746
substrate	containing	lauric acid	Production of poly(3-hydroxybutyrate- co-3-hydroxyhexanoate) with flexible 3-hydroxyhexanoate content in Aeromonas hydrophila CGMCC 0911.	1	30.9145
nucleoside	derived-from	substrate	Utilization of nucleoside monophosphates per Se for intraperiplasmic growth of Bdellovibrio bacteriovorus.	1	30.8855
kDa protein	associated-with	substrate	Amplification of a Streptomyces lividans 4.3 kb DNA element causes overproduction of a novel hypha- and vesicle-associated protein.	1	30.7012
substrate	associated-with	cholesterol	Higher cholesterol in human LDL is associated with the increase of oxidation susceptibility and the decrease of antioxidant defence: experimental and simulation data.	1	30.7012
substrate	associated-with	cerebral palsy	Cytokine immunoreactivity in cortical and subcortical neurons in periventricular leukomalacia: are cytokines implicated in neuronal dysfunction in cerebral palsy?	1	30.7012
substrate	associated-with	cardiomyopathy	Characterization of the electroanatomic substrate for monomorphic ventricular tachycardia in patients with nonischemic cardiomyopathy.	1	30.7012
arachidonic acid	serves-as	substrate	Ischemic brain injury: the importance of calcium, lipolytic activities, and free fatty acids.	5	30.591
substrate	derived-from	phenylalanine	Computation of enzyme-substrate specificity.	1	30.532
formamidase	having	substrate	New formamidase having substrate specificity for o-formylaminoacetophenone in pig liver.	2	30.4103
substrate	containing	protein	Cyclic AMP-stimulated phosphorylation of bovine tracheal smooth muscle contractile and non-contractile proteins.	2	30.0746
substrate	containing	lysine	Engineering the substrate specificity of rhizopuspepsin: the role of Asp 77 of fungal aspartic proteinases in facilitating the cleavage of oligopeptide substrates with lysine in P1.	2	30.0746
substrate	containing	hydrogen	Dot-enzyme immunoassay for visual detection of antibodies to pseudorabies virus in swine serum.	2	30.0746
substrate	containing	thymine	Nucleotide excision repair 3' endonuclease XPG stimulates the activity of base excision repairenzyme thymine glycol DNA glycosylase.	2	30.0656
tryptophan	involved-in	substrate	Implication of tryptophan and histidine in the active site of endo-polygalacturonase from Aspergillus ustus: elucidation of the reaction mechanism.	2	30.052
substrate	involved-in	pathogenesis	Oral contraceptives--induced hypertension--nine years later.	2	30.052
substrate	exists-in	cat	Fine structural organization of spinothalamic and trigeminothalamic lamina I terminations in the nucleus submedius of the cat.	1	29.9331
substrate	converted-into	testosterone	Optimization of a classical aromatase activity assay and application in normal, adenomatous and malignant breast parenchyma.	1	29.8242
substrate	converted-to	bilirubin	Bilirubin diglucuronide synthesis by a UDP-glucuronic acid-dependent enzyme system in rat liver microsomes.	1	29.8242
substrate	converted-to	cortisone	In vitro metabolism of cortisol by human abdominal adipose tissue.	1	29.8242
phospholipase	cause	substrate	The effect of coenzyme Q10 on the action of phospholipase.	1	29.7013
beta-estradiol	caused	substrate	Characterization of guinea pig estrogen sulfotransferase expressed by Chinese hamster ovary cell-K1 stable transfectants.	1	29.7013
Fluoride	caused	substrate	Substrate inhibition of rat liver and kidney arginase with fluoride.	1	29.7013
arginine	essential	substrate	[Modification of arginine residues in pyruvate kinase (author's transl).]	1	29.6425
formate	released-from	substrate	Studies on the 14 alpha-demethylation mechanism in cholesterol biosynthesis.	1	29.5801
peroxide	followed	substrate	Stability of virgin olive oil. 1. Autoxidation studies.	1	29.5174
L-malate	follow	substrate	Kinetic mechanism of the cytosolic malic enzyme from human breast cancer cell line.	1	29.5174
substrate	following	hypertension	Plasma renin activity, reactivity, concentration and substrate following hypertension during pregnancy. Effect of oral contraceptive agents.	1	29.5174
substrate	follow	iodoacetic acid	Heme binding and substrate-protected cysteine residues in P-450cam.	1	29.5174
proteolysis	includes	substrate	Kinetic description of proteolysis. Part 1. Peptic hydrolysis of proteins isolated from chicken heart: optimization in terms of time and substrate concentration.	1	29.4205
substrate	including	glycine	Engineering of S2 site of aqualysin I; alteration of P2 specificity by excluding P2 side chain.	1	29.4205
target enzyme	have	substrate	Metabolic analysis in drug design.	1	29.4103
lyase	had	substrate	An effective method for isolating alginate lyase-producing Bacillus sp. ATB-1015 strain and purification and characterization of the lyase.	1	29.4103
plant enzyme	has	substrate	The role of pyridoxal 5'-phosphate in plant phosphorylase.	1	29.4103
substrate	had	cellulase	Bioprocessing of sweet sorghum with in situ-produced enzymes.	1	29.4103
substrate	had	chlorine	Dechlorination and para-hydroxylation of polychlorinated phenols by Rhodococcus chlorophenolicus.	1	29.4103
tritium	released-from	substrate	New assay for pregnenolone and progesterone 17alpha- hydroxylase based on the specific substitution of a tritium situated on carbon 17.	1	29.3523
mannose	released-from	substrate	A spectrophotometric assay for alpha-mannosidase activity.	1	29.3523
butyric acid	released-from	substrate	A colorimetric assay of pancreatic lipase: rapid detection of lipase and colipase separated by gel filtration.	1	29.3523

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