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Entity 1
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Relationship
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Entity 2
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Article
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Frequency
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Score
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| dopamine | released-from | substantia | Dopamine D1 heteroreceptors on striatonigral axons are not stimulated by endogeneous dopamine either tonically or after amphetamine: evidence from terminal excitability. | 2 | 37.5409 |
| acetylcholinesterase | released-from | substantia | The influence of electrical stimulation of certain brain regions on the concentration of acetylcholinesterase in rabbit cerebrospinal fluid. | 3 | 35.7113 |
| lesions | not-occur-in | substantia | Transsynaptic cell death of neurons following striatopallidal lesions does not occur in substantia nigra pars reticulata in developing rats. | 1 | 31.1822 |
| glutathione | occurs-in | substantia | Alterations in the distribution of glutathione in the substantia nigra in Parkinson's disease. | 1 | 29.8389 |
| apoptosis | occurs-in | substantia | Neuron death in the substantia nigra of weaver mouse occurs late in development and is not apoptotic. | 2 | 29.7744 |
| gabapentin | included | substantia | Gabapentin increases aminooxyacetic acid-induced GABA accumulation in several regions of rat brain. | 1 | 29.4205 |
| nervous system lymphoma | involving | substantia | Parkinsonian syndrome and central nervous system lymphoma involving the substantia nigra. A case report. | 1 | 29.052 |
| deficiency | identified-in | substantia | Mitochondrial function in Parkinson's disease. The Royal Kings and Queens Parkinson's Disease Research Group. | 2 | 29.0148 |
| enzyme | occurs-in | substantia | Angiotensin II receptor binding associated with nigrostriatal dopaminergic neurons in human basal ganglia. | 1 | 28.7744 |
| lesion | made-in | substantia | The effect of blocking dopamine release on synthesis rate of dopamine in the striatum of the rat. | 2 | 28.4102 |
| substantia | influence | seizures | Seizures in the developing brain. | 1 | 27.3172 |
| proteins | absent | substantia | Expression of immediate early gene proteins following axotomy and inhibition of axonal transport in the rat central nervous system. | 1 | 25.3694 |
| monkeys | severe | substantia | Decreased tyrosine hydroxylase content in the dopaminergic neurons of MPTP-intoxicated monkeys: effect of levodopa and GM1 ganglioside therapy. | 1 | 25.0775 |
| dialysate | smaller | substantia | 3-Methoxytyramine formation following monoamine oxidase inhibition is a poor index of dendritic dopamine release in the substantia nigra. | 1 | 24.5553 |
| protein | apparent | substantia | Descending pathways from the superior collicullus: an autoradiographic analysis in the rhesus monkey (Macaca mulatta). | 1 | 24.4965 |
| spiperone | normal | substantia | [3H]spiperone binding, dopamine and HVA concentrations in Parkinson's disease and supranuclear palsy. | 1 | 24.4012 |
| rats | lesioned-in | substantia | Stimulant properties of bromocriptine on central dopamine receptors in comparison to apomorphine, (+)-amphetamine and L-DOPA. | 5 | 14.6334 |
| 6-hydroxydopamine | injected-into | substantia | Partial striatal dopamine depletion differentially affects striatal substance P and enkephalin messenger RNA expression. | 3 | 10.6783 |
| iron | increased-in | substantia | Complex I, iron, and ferritin in Parkinson's disease substantia nigra. | 2 | 10.3345 |
| kainic acid | lesioning-of | substantia | GABA and benzodiazepine receptors in the cat motor thalamus after lesioning of nigro- and pallidothalamic pathways. | 1 | 9.8256 |
| baclofen | injected-into | substantia | Rotational behavior induced in rats by intranigral application of GABA-related drugs and GABA antagonists. | 2 | 9.6783 |
| muscimol | injected-into | substantia | Regional distribution of the anticonvulsant and behavioural effects of muscimol injected into the substantia nigra of rats. | 2 | 9.6783 |
| kainate | increased-in | substantia | Excitatory amino acid receptor regulation after subthalamic nucleus lesions in the rat. | 1 | 9.3345 |
| norepinephrine | increased-in | substantia | Effect of nicotine on extracellular levels of neurotransmitters assessed by microdialysis in various brain regions: role of glutamic acid. | 1 | 9.3345 |
| aluminium | increased-in | substantia | Effects of complexed iron and aluminium on brain calcium. | 1 | 9.3345 |
| uric acid | reduced-in | substantia | Uric acid is reduced in the substantia nigra in Parkinson's disease: effect on dopamine oxidation. | 1 | 9.1577 |
| peptide | binds-to | substantia | Quantitative autoradiography of [125I] apamin binding sites in the central nervous system. | 1 | 8.7795 |
| transpeptidase | observed-in | substantia | Effect of acute administration of 1,2,3,4-tetrahydroisoquinoline on the levels of glutathione and reactive oxygen species, and on the enzymatic activity of gamma-glutamyl transpeptidase in dopaminergic structures of rat brain. | 1 | 8.7562 |
| Zn | observed-in | substantia | Regional distribution of manganese, iron, copper, and zinc in the rat brain during development. | 1 | 8.7562 |
| stress | observed-in | substantia | Glial cells and inflammation in Parkinson's disease: a role in neurodegeneration? | 1 | 8.7562 |
| gliosis | observed-in | substantia | Tau phosphorylation and kinase activation in familial tauopathy linked to deln296 mutation. | 1 | 8.7562 |
| nitric oxide synthase | not-observed-in | substantia | Nitric oxide synthase inhibition and MPTP-induced toxicity in the common marmoset. | 1 | 8.7562 |
| 5-hydroxyindoleacetic acid | observed-in | substantia | Subchronic toxicity of PCB 105 (2,3,3',4,4'-pentachlorobiphenyl) in rats. | 1 | 8.7562 |
| procaine | injected-into | substantia | Ipsilateral hemiconvulsive seizure after unilateral injection of procaine into the substantia innominata of amygdaloid-kindled rats. | 1 | 8.6783 |
| leucine | injected-into | substantia | The interhemispheric projection from the substantia nigra to the caudate-putamen as depicted by the anterograde transport of [3H]leucine. | 1 | 8.6783 |
| reserpine | injected-into | substantia | Axonal transport of dopamine-containing vesicles labelled in vivo with [3H]reserpine. | 1 | 8.6783 |
| 2-chloroadenosine | injected-into | substantia | Anticonvulsant action of 2-chloroadenosine injected focally into the inferior colliculus and substantia nigra. | 1 | 8.6783 |
| movement disorders | affecting | substantia | Sexual dimorphism and developmental regulation of substantia nigra function. | 1 | 8.5954 |
| rat | not-limited-to | substantia | Neuropeptide FF in the lateral spinal and lateral cervical nuclei: evidence of contacts on spinothalamic neurons. | 1 | 8.5255 |
| soma | found-in | substantia | Fluoride-resistant acid phosphatase (FRAP)-positive afferent terminals make synaptic contact with interneuronal soma in the substantia gelatinosa of the mouse spinal dorsal horn. | 1 | 8.423 |
| Fe | found-in | substantia | Is Parkinson's disease the heterozygote form of Wilson's disease: PD = 1/2 WD? | 1 | 8.423 |
| asphyxia | found-in | substantia | Perinatal asphyxia increases bFGF mRNA levels and DA cell body number in the mesencephalon of rats. | 1 | 8.423 |
| allopregnanolone | seen-in | substantia | Progesterone, 5alpha-pregnane-3,20-dione and 3alpha-hydroxy-5alpha-pregnane-20-one in specific regions of the human female brain in different endocrine states. | 1 | 8.044 |
| deficiencies | detected-in | substantia | Erythrocyte antioxidant activity in human patients with Parkinson's disease. | 1 | 7.8244 |
| adenosine | examined-in | substantia | Regulation by equilibrative nucleoside transporter of adenosine outward currents in adult rat spinal dorsal horn neurons. | 1 | 7.7833 |
| excess iron | reported-in | substantia | Cysteamine pretreatment of the astroglial substratum (mitochondrial iron sequestration) enhances PC12 cell vulnerability to oxidative injury. | 1 | 7.7799 |
| glutamate | interact-in | substantia | GABA and glutamate interact in the substantia innominata/lateral preoptic area to modulate locomotor activity. | 1 | 7.4362 |
| 6-tetrahydropyridine | infused-into | substantia | Biochemical changes caused by the infusion into the substantia nigra of the rat of MPTP and related compounds which antagonise dihydropteridine reductase. | 1 | 7.3226 |
| rotenone | infused-into | substantia | Behavioral differences in a rotenone-induced hemiparkinsonian rat model developed following intranigral or median forebrain bundle infusion. | 1 | 7.3226 |
| latex microspheres | infused-into | substantia | Dopamine receptor distribution in the rat CNS: elucidation using anti-peptide antisera directed against D1A and D3 subtypes. | 1 | 7.3226 |
