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Entity 2
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| Adriamycin | not-contain | P-glycoprotein | Mechanisms of multidrug resistance in HL60 cells. Analysis of resistance associated membrane proteins and levels of mdr gene expression. | 1 | 33.1841 |
| Adriamycin | inhibitors | topoisomerase | Topoisomerase poisons differentially activate DNA damage checkpoints through ataxia-telangiectasia mutated-dependent and -independent mechanisms. | 1 | 29.4951 |
| breast cancer | include | Adriamycin | Adriamycin versus methotrexate in five-drug combination chemotherapy for advanced breast cancer: a randomized trial. | 1 | 29.4205 |
| Adriamycin | has | quinone | Potentiation of adriamycin toxicity by ethanol in perfused rat liver. | 1 | 29.4103 |
| Adriamycin | studied-in | mouse | Cytotoxicity and DNA strand breaks by 5-iminodaunorubicin in mouse leukemia L1210 cells: comparison with adriamycin and 4'-(9-acridinylamino)methanesulfon-m-anisidide. | 1 | 28.6074 |
| P388 leukemia | resistant | Adriamycin | In vivo and in vitro anticancer activity of the structurally novel and highly potent antibiotic CI-940 and its hydroxy analog (PD 114,721). | 1 | 27.2577 |
| esophagus | sensitive | Adriamycin | Modified administration schedule of adriamycin in solid tumors. | 1 | 27.2265 |
| Adriamycin | active | daunorubicin | Effect of daunorubicin and adriamycin on nucleic acid synthesis of serum stimulated mouse embryo fibroblasts. | 1 | 26.8493 |
| P-glycoprotein | determinant | Adriamycin | P-glycoprotein expression and schedule dependence of adriamycin cytotoxicity in human colon carcinoma cell lines. | 1 | 24.8712 |
| Adriamycin | reactive | iron | Adriamycin-induced oxidation of myoglobin. | 1 | 24.5835 |
| lesions | greatest | Adriamycin | Bladder epithelial hyperplasia in F344 rats after intravesical instillation of the antitumor chemotherapeutic agents Adriamycin and mitomycin C. | 1 | 24.3322 |
| rats | treated-with | Adriamycin | New approaches to the possible prevention of side effects of chemotherapy by nutrition. | 3 | 17.16 |
| mice | treated-with | Adriamycin | Increased primary cell-mediated immunity in culture subsequent to adriamycin or daunorubicin treatment of spleen donor mice. | 5 | 14.6051 |
| Adriamycin | induces | proteinuria | Effects of enalapril on adriamycin-induced nephrosis. | 1 | 13.8089 |
| Adriamycin | reduced | glutathione | Effect of riboflavin-butyrate on cardiac glutathione reductase affected by adriamycin. | 1 | 12.8769 |
| Adriamycin | sustained-except | vincristine | Effect of vincristine, adriamycin and glucocorticoids on myeloma cells in vitro. | 1 | 12.7788 |
| Adriamycin | induces | nephrotic syndrome | Steroids and Adriamycin nephrosis. | 1 | 12.0603 |
| tumors | treated-with | Adriamycin | Modified administration schedule of adriamycin in solid tumors. | 2 | 11.6051 |
| sarcoma | treated-with | Adriamycin | Successful treatment of metastatic sarcomas with cyclophosphamide, adriamycin, and DTIC (CAD). | 2 | 11.6051 |
| Adriamycin | inhibited | tumor | Specific targeting and killing activities of anti-P-glycoprotein monoclonal antibody MRK16 directed against intrinsically multidrug-resistant human colorectal carcinoma cell lines in the nude mouse model. | 2 | 11.5971 |
| Adriamycin | used-in | sarcoma | Hepatic intra-arterial adriamycin in metastatic leiomyosarcoma: exploiting the steep dose-response curve. | 1 | 11.3187 |
| Adriamycin | inhibited | protein | Effect of adriamycin on DNA, RNA, and protein synthesis in cell-free systems and intact cells. | 2 | 10.7851 |
| verapamil | not-reverse | Adriamycin | Reduced DNA topoisomerase II activity and drug-induced DNA cleavage activity in an adriamycin-resistant human small cell lung carcinoma cell line. | 1 | 10.7108 |
| tumor | treated | Adriamycin | Radiologic recognition of adriamycin cardiotoxicity. | 1 | 10.6051 |
| leiomyosarcoma | treated-with | Adriamycin | Heterologous sarcomas of the uterus. | 1 | 10.6051 |
| rabbits | treated-with | Adriamycin | Failure of the antioxidant vitamin E to protect against adriamycin-induced cardiotoxicity in the rabbit. | 1 | 10.6051 |
| osteosarcomas | treated-with | Adriamycin | Anticancer drug screening test with LDH in nude mouse bearing bone and soft part sarcoma. | 1 | 10.6051 |
| pigs | treated-with | Adriamycin | Reduction of adriamycin toxicity by ascorbate in mice and guinea pigs. | 1 | 10.6051 |
| Adriamycin | induces | albuminuria | Glomerular sieving of anionic and neutral bovine albumins in proteinuric rats. | 1 | 10.1962 |
| Adriamycin | induced | esophageal atresia | Dose response relationship between adriamycin and birth defects in a rat model of VATER association. | 1 | 10.1962 |
| Adriamycin | induced | hyperlipemia | Adriamycin causes hyperlipemia as a consequence of nephrotoxicity. | 1 | 10.1962 |
| Adriamycin | react-with | formaldehyde | Activation of adriamycin by the pH-dependent formaldehyde-releasing prodrug hexamethylenetetramine. | 1 | 9.961 |
| bladder tumors | using | Adriamycin | [Prevention of recurrence in non-invasive bladder carcinoma. Experiences with 400 patients] | 1 | 9.7862 |
| Adriamycin | using | phosphorothioate | Concerning antisense inhibition of the multiple drug resistance gene. | 1 | 9.7862 |
| Adriamycin | inhibited | adenosine | Cardiac sodium, potassium-adenosine triphosphatase as a possible site of adriamycin-induced cardiotoxicity. | 1 | 9.7851 |
| Adriamycin | inhibits | potassium | Inhibition of sodium-potassium-activated adenosine 5'-triphosphatase and ion transport by adriamycin. | 1 | 9.7851 |
| Adriamycin | inhibits | histone | Topoisomerase poisons differentially activate DNA damage checkpoints through ataxia-telangiectasia mutated-dependent and -independent mechanisms. | 1 | 9.7851 |
| Adriamycin | conjugated-through | dextran | Sensitivity of multidrug resistant KB-C1 cells to an antibody-dextran-adriamycin conjugate. | 1 | 9.717 |
| Sprague-Dawley rats | injected-with | Adriamycin | Fibroblast growth factor signaling in the developing tracheoesophageal fistula. | 2 | 9.6783 |
| Adriamycin | treated | mice | Induction of suppressor T cells in culture--II. Modification by adriamycin. | 1 | 9.5387 |
| Adriamycin | administered-to | rats | Effect of metoprolol on activity of beta-adrenoceptor coupled to guanine nucleotide binding regulatory proteins in adriamycin-induced cardiotoxicity. | 2 | 9.5299 |
| Adriamycin | stimulated | superoxide | Endothelial nitric oxide synthase-dependent superoxide generation from adriamycin. | 1 | 9.4814 |
| hamsters | received | Adriamycin | Electron microscopic studies of the heart and light microscopic studies of the skin after treatment of golden hamsters with adriamycin, detorubicin, AD-32, and aclacinomycin. | 1 | 9.3957 |
| Adriamycin | received | hexamethylmelamine | Hexamethylmelamine in ovarian cancer resistant to cyclophosphamide and adriamycin. | 1 | 9.3957 |
| Adriamycin | increased | pentose phosphate | Adriamycin resistance in human tumor cells associated with marked alteration in the regulation of the hexose monophosphate shunt and its response to oxidant stress. | 1 | 9.3345 |
| Adriamycin | induced | histamine | Evidence of an adriamycin binding site in the secretory granules of the mast cell. | 1 | 9.1725 |
| borohydride | reduced | Adriamycin | Reductive activation of diaziquone and possible involvement of free radicals and the hydroquinone dianion. | 1 | 9.1577 |
| Adriamycin | reduced | angiogenesis | Antiangiogenic chemotherapeutic agents: characterization in comparison to their tumor growth inhibition in human renal cell carcinoma models. | 1 | 9.1577 |
| methotrexate | compared-to | Adriamycin | Chemotherapy of extensive large cell and adenocarcinoma of the lung: a randomized trial in 210 patients. | 1 | 8.9923 |
| Adriamycin | bound-to | sulfatide | Effect of adriamycin entrapped by sulfatide-containing liposomes on ovarian tumor-bearing nude mice. | 1 | 8.7795 |
