Relationships for activates
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| citrate | activates | enzyme | Regulation of mitochondrial malate dehydrogenase. Evidence for an allosteric citrate-binding site. |
| insulin | activates | protein kinase | Protein phosphorylation and protein kinase activities in BC3H-1 myocytes. Differences between the effects of insulin and phorbol esters. |
| insulin | activates | serine kinase | Protein kinase activity of the insulin receptor. |
| phorbol myristate acetate | activates | protein kinase | Calcium dependent activation of the NF-AT transcription factor by p59fyn. |
| protein | activates | phosphatidylinositol | Extracellular HIV-1 Tat protein activates phosphatidylinositol 3- and Akt/PKB kinases in CD4+ T lymphoblastoid Jurkat cells. |
| phorbol-12-myristate-13-acetate | activates | protein kinase | Loss of copper-zinc superoxide dismutase gene expression in differentiated cells of myelo-monocytic origin. |
| lactone | activates | protein kinase | Bryostatin 1: a potential anti-leukemic agent for chronic myelomonocytic leukemia. |
| hemolysate | activates | tyrosine kinase | Tyrosine phosphorylation and [Ca2+]i elevation induced by hemolysate in bovine endothelial cells: implications for cerebral vasospasm. |
| hormone | activates | phospholipase | Thyroid-stimulating hormone activates phospholipase C in normal and neoplastic thyroid tissue. |
| estrogen | activates | telomerase | Estrogen activates telomerase. |
| peptide | activates | yeast | A trans-acting peptide activates the yeast a1 repressor by raising its DNA-binding affinity. |
| histamine | activates | tyrosine | Activation of tyrosine hydroxylase by histamine in bovine chromaffin cells. |
| apomorphine | activates | dopamine | Apomorphine is a highly potent free radical scavenger in rat brain mitochondrial fraction. |
| dichloroacetate | activates | pyruvate | [Effects of dichloroacetate and 2-chloropropionate on carbohydrate metabolism of isolated hepatocytes. Therapeutic applications] |
| insulin | activates | farnesyl transferase | Effect of insulin on farnesyltransferase. Specificity of insulin action and potentiation of nuclear effects of insulin-like growth factor-1, epidermal growth factor, and platelet-derived growth factor. |
| histamine | activates | Cl | Histamine activates chloride conductance in motor neurons of the lobster cardiac ganglion. |
| protease | activates | protein kinase | Differential activation of two protease-activated protein kinases from reticulocytes by a Ca2+-stimulated protease and identification of phosphorylated translational components. |
| enzyme | activates | plasminogen | Migration of Schwann cells and wrapping of neurites in vitro: a function of protease activity (plasmin) in the growth medium. |
| protein | activates | chloride | A GTP-binding protein activates chloride channels in a renal epithelium. |
| glucose | activates | phospholipase | Ether-linked lysophospholipids initiate insulin secretion. Lysophospholipids may mediate effects of phospholipase A2 activation on hormone release. |
| enzyme | activates | methylene chloride | Isolation of a mouse theta glutathione S-transferase active with methylene chloride. |
| zinc | activates | protein kinase | Effects of zinc on the reactive oxygen species generating capacity of human neutrophils and on the serum opsonic activity in vitro. |
| enzyme | activates | long-chain fatty acids | Characteristics and subcellular localization of pristanoyl-CoA synthetase in rat liver. |
| diabetes | activates | osteogenic | Diet-induced diabetes activates an osteogenic gene regulatory program in the aortas of low density lipoprotein receptor-deficient mice. |
| lysophosphatidic acid | activates | phosphoinositide 3-kinase | Wortmannin inhibits serum-induced activation of phosphoinositide 3-kinase and proliferation of CHRF-288 cells. |
| ischemia | activates | cardiovascular system | Hydrogen peroxide-induced cardiovascular reflexes. Role of hydroxyl radicals. |
| N-methyl-D-aspartate | activates | glutamate | Developmental changes in the effects of serotonin and N-methyl-D-aspartate on intrinsic membrane properties of embryonic chick motoneurons. |
| serine proteinase | activates | zymogen | Tissue-type plasminogen activator and neuroserpin: a well-balanced act in the nervous system? |
| Cre recombinase | activates | beta-galactosidase | Adeno-associated virus effectively mediates conditional gene modification in the brain. |
| kinase kinase kinase | activates | c-Jun N-terminal kinase | Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1. |
| ceramide | activates | protein kinase | Ceramide directly activates protein kinase C zeta to regulate a stress-activated protein kinase signaling complex. |
| rat | activates | apoptosis | Relationship between the ubiquitin-dependent pathway and apoptosis in different cells of the central nervous system: effect of thyroid hormones. |
| bradykinin | activates | protein kinase | Bradykinin activates protein kinase C in cultured cortical collecting tubular cells. |
| phorbol ester 12-O-tetradecanoylphorbol-13-acetate | activates | protein kinase | A protein kinase inhibitor, staurosporine, mimics nerve growth factor induction of neurotensin/neuromedin N gene expression. |
| antigen | activates | phospholipase | Calcium/calmodulin-dependent protein kinase II downregulates both calcineurin and protein kinase C-mediated pathways for cytokine gene transcription in human T cells. |
| antigen | activates | phosphatidylinositol | Activation of protein kinase C in rat basophilic leukemia cells stimulates increased production of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate: correlation with actin polymerization. |
| shock | activates | opiate analgesia | Influence of naloxone on shock-induced freezing and analgesia. |
| enzyme | activates | acetoacetate | The regulation of acetoacetyl-CoA synthetase activity by modulators of cholesterol synthesis in vivo and the utilization of acetoacetate for cholesterogenesis. |
| insulin | activates | pentose phosphate | Short-term control of the pentose phosphate cycle by insulin could be modulated by the NADPH/NADP ratio in rat adipocytes and hepatocytes. |
| hedgehog | activates | hematopoiesis | Indian hedgehog activates hematopoiesis and vasculogenesis and can respecify prospective neurectodermal cell fate in the mouse embryo. |
| enzyme | activates | metronidazole | Drug targets and mechanisms of resistance in the anaerobic protozoa. |
| retinoic acid | activates | human secretin | Retinoic acid activates human secretin gene expression by Sp proteins and nuclear factor I in neuronal SH-SY5Y cells. |
| enzyme | activates | trypsinogen | Trypsinogen-kinase from Aspergillus fumigatus. |
| salicylate | activates | pyruvate | Inhibition of hepatic lipogenesis by salicylate. |
| acid | activates | organophosphate | Paraoxon and parathion hydrolysis by aqueous molybdenocene dichloride (Cp2MoCl2): first reported pesticide hydrolysis by an organometallic complex. |
| ketoconazole | activates | chloride | Ketoconazole activates chloride and fluid secretion by Necturus gallbladder at low pH. |
| glimepiride | activates | glucose | The sulfonylurea drug, glimepiride, stimulates glucose transport, glucose transporter translocation, and dephosphorylation in insulin-resistant rat adipocytes in vitro. |
| arachidonic acid | activates | nadph oxidase | Arachidonic acid activates NADPH oxidase by a direct, calmodulin-regulated mechanism. |
| ganglioside | activates | sphingosine kinase | The lysophospholipids sphingosine-1-phosphate and lysophosphatidic acid enhance survival during hypoxia in neonatal rat cardiac myocytes. |
| oestrogen | activates | gonadotropin | Evidence in favour of a direct input from the ventromedial nucleus to gonadotropin-releasing hormone neurones in the ewe: an anterograde tracing study. |
