Relationships for essential
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| zinc | essential | spermatogenesis | Zinc deficiency in human subjects. |
| telomerase | essential | enzyme | A functional telomerase RNA swap in vivo reveals the importance of nontemplate RNA domains. |
| angiogenesis | essential | carcinogenesis | Correlation between proliferation, apoptosis, and angiogenesis in prostate carcinoma and their relation to androgen ablation. |
| carnitine | essential | fatty acid | Improvement of myocardial fatty acid metabolism through L-carnitine administration to chronic hemodialysis patients. |
| bile acids | essential | cholesterol | Effects of colestipol hydrochloride on cholesterol and bile acids absorption in the rat intestinal tract. |
| K-ras | essential | mouse | While K-ras is essential for mouse development, expression of the K-ras 4A splice variant is dispensable. |
| oxidase | essential | mice | Hyperuricemia and urate nephropathy in urate oxidase-deficient mice. |
| racemase | essential | bile acid | Peroxisomal beta-oxidation of 2-methyl-branched acyl-CoA esters: stereospecific recognition of the 2S-methyl compounds by trihydroxycoprostanoyl-CoA oxidase and pristanoyl-CoA oxidase. |
| iron | essential | megakaryopoiesis | Idiopathic thrombocytopenic purpura presenting as iron-responsive thrombocytopenia. |
| epinephrine | essential | fibrinogen | Protein kinase C activation is not a key step in ADP-mediated exposure of fibrinogen receptors on human platelets. |
| thioredoxin reductase | essential | embryogenesis | Cytoplasmic thioredoxin reductase is essential for embryogenesis but dispensable for cardiac development. |
| enzyme | essential | embryogenesis | An Arabidopsis RNA lariat debranching enzyme is essential for embryogenesis. |
| protease | essential | hepatitis | Genetic heterogeneity of the NS3 protease gene in hepatitis C virus genotype 1 from untreated infected patients. |
| protein | essential | uracil | A PEST-like sequence mediates phosphorylation and efficient ubiquitination of yeast uracil permease. |
| protein | essential | thiamine | Mechanism of ligand-protein interaction in plant seed thiamine-binding proteins. Preliminary chemical identification of amino acid residues essential for thiamine binding to the buckwheat-seed protein. |
| protein | essential | organogenesis | The T/ebp null mouse: thyroid-specific enhancer-binding protein is essential for the organogenesis of the thyroid, lung, ventral forebrain, and pituitary. |
| iron | essential | productive infection | Potential role for extracellular glutathione-dependent ferric reductase in utilization of environmental and host ferric compounds by Histoplasma capsulatum. |
| alpha-ketoglutarate | essential | amino | Cooperation between Lactococcus lactis and nonstarter lactobacilli in the formation of cheese aroma from amino acids. |
| atrial fibrillation | essential | arrhythmia | [Drug treatments of atrial fibrillation] |
| transmembrane proteins | essential | gamma-secretase | Neuronal deficiency of presenilin 1 inhibits amyloid plaque formation and corrects hippocampal long-term potentiation but not a cognitive defect of amyloid precursor protein [V717I] transgenic mice. |
| Calcium | essential | esterase | Methacholine-stimulated release of benzoyl-arginine-ethylester esterase from mouse submandibular gland cells. |
| Calcium | essential | enzyme | In vitro phenoloxidase activity in the blood of Ciona intestinalis and other ascidians. |
| Calcium | essential | lysis | Differential sensitivity of Trypanosoma brucei rhodesiense isolates to in vitro lysis by arsenicals. |
| PI-3 kinase | essential | protein | A membrane-associated complex containing the Vps15 protein kinase and the Vps34 PI 3-kinase is essential for protein sorting to the yeast lysosome-like vacuole. |
| lipoic acid | essential | mouse | Endogenous production of lipoic acid is essential for mouse development. |
| anhydrase | essential | photosynthesis | Intracellular carbonic anhydrase is essential to photosynthesis in Chlamydomonas reinhardtii at atmospheric levels of CO2. Demonstration via genomic complementation of the high-CO2-requiring mutant ca-1. |
| diacylglycerol | essential | glucose | Diacylglycerol hydrolysis to arachidonic acid is necessary for insulin secretion from isolated pancreatic islets: sequential actions of diacylglycerol and monoacylglycerol lipases. |
| phenol | essential | benzene | Mode of action of butylated hydroxyanisole (BHA) and other phenols in preventing loss of 11 beta-hydroxylase activity in cultured bovine adrenocortical cells. |
| coat protein | essential | infection | Replication of wheat dwarf virus DNA in protoplasts and analysis of coat protein mutants in protoplasts and plants. |
| cholesterol | essential | macrophage inflammatory protein | Cholesterol is essential for macrophage inflammatory protein 1 beta binding and conformational integrity of CC chemokine receptor 5. |
| protein | essential | vitellogenesis | Visualization of the chicken oocyte lipoprotein receptor by ligand blotting with biotinylated plasma and yolk very low density lipoproteins. |
| protein | essential | syncytium | Palmitoylation, membrane-proximal basic residues, and transmembrane glycine residues in the reovirus p10 protein are essential for syncytium formation. |
| hypoxic pulmonary hypertension | essential | pathogenesis | Nifedipine for high altitude pulmonary oedema. |
| pyrophosphorylase | essential | protein | Saccharomyces cerevisiae VIG9 encodes GDP-mannose pyrophosphorylase, which is essential for protein glycosylation. |
| systolic hypertension | essential | hypertension | Effects of isolated systolic hypertension and essential hypertension on large and middle-sized artery compliance. |
| cell membrane proteins | essential | cholesterol | Inhibition of cholesterol efflux by 7-ketocholesterol: comparison between cells, plasma membrane vesicles, and liposomes as cholesterol donors. |
| diethyl pyrocarbonate | essential | translocation atpase | Histidine residues are involved in translocation-coupled ATP hydrolysis by the Sec-A protein. |
| cell surface proteoglycans | essential | infection | Cell surface proteoglycans are not essential for infection by pseudorabies virus. |
| chemotaxis proteins | essential | viral structural protein | Stable expression of transdominant Rev protein in human T cells inhibits human immunodeficiency virus replication. |
| N-propeptide | essential | collagen | The globular domain of the proalpha 1(I) N-propeptide is not required for secretion, processing by procollagen N-proteinase, or fibrillogenesis of type I collagen in mice. |
| gastric alcohol dehydrogenase | essential | alcohol | Gastric metabolism of ethanol in Syrian golden hamster. |
| 12-kDa protein | essential | oxygen | Analysis of the psbU gene encoding the 12-kDa extrinsic protein of photosystem II and studies on its role by deletion mutagenesis in Synechocystis sp. PCC 6803. |
| B-subunit | essential | substrate | Calcineurin is a calcium ion-dependent, calmodulin-stimulated protein phosphatase. |
| lactosylceramide | essential | osteoclastogenesis | Lactosylceramide is essential for the osteoclastogenesis mediated by macrophage-colony-stimulating factor and receptor activator of nuclear factor-kappa B ligand. |
| rna helicase | essential | nitrogen | The ste13+ gene encoding a putative RNA helicase is essential for nitrogen starvation-induced G1 arrest and initiation of sexual development in the fission yeast Schizosaccharomyces pombe. |
| mitochondrial superoxide dismutase | essential | ethanol | Mitochondrial superoxide dismutase is essential for ethanol tolerance of Saccharomyces cerevisiae in the post-diauxic phase. |
| protein | essential | natural infection | Interaction of hepatitis B virus X protein with damaged DNA-binding protein p127: structural analysis and identification of antagonists. |
| protein | essential | synaptic vesicle exocytosis | Role of the conserved WHXL motif in the C terminus of synaptotagmin in synaptic vesicle docking. |
| anhydride | essential | enzyme | Specific acetylation of essential lysine residues in malonyl-CoA decarboxylase. |
| insulin receptor | essential | glucose | Crystal structure of the first three domains of the type-1 insulin-like growth factor receptor. |
